This poses a difficult question - which I face as a farmer. I am obliged by law to control the rats around my grain store, but there are owls locally which I desperately want to protect.
I heard about an owl safe poison - Eradirat - which is basically pure cellulose. The rats can't digest this, so die of starvation. However, the word is out that this worked fine in the labs, where test rats had nothing else to eat. On farm, rats aren't stupid enough to eat it when there is plenty other feed about, it simply isn't attractive enough.
What do I do ?
1. I tip the sweepings from the grain store at an open site well away from the steading (farm buildings) where they will hopefully attract rats away from the steading. This site is pretty much home to a buzzard, good start.
2. I maximise use of traps. These help, but when the weather is really bad - as it has been the last two winters, rats move in, in numbers.
3. We use poison only inside to try to keep affected rats away from owls.
4. We use poisons with as quick action as possible, to try to get the rats dead before they can move within reach of the owls.
Note this point - deliberately using the most potent poison available. the reason for this is that rats develop tolerance of poisons. This caused problems with the red kite re-introduction programme along the M4 corridor in England. Rats ate poison but in many cases remained mobile. They were then taken and eaten by kites, which had no tolerance of the poison and were killed. I understand the problem was overcome by moving to poisons for which the rats had not developed tolerance.
5. We get the store empty and clean it thoroughly as long before harvest as we can to encourage the rats to get out and stay out.
Incidentally we asked for a design for the new grain store that would be rat proof. Essentially only silos can be made rat proof (and those were unsuitable for all our storage). Rats can deform their skulls, allowing them to squeeze through gaps of about 10mm (incredible isn't it) and are also amazing climbers, incredibly intelligent, and well versed in avoiding the perils devised by man. For instance, a trap will only work if it has no trace of human scent. We wear gloves and rub them in soil before touching the traps (tactics learned from mole catchers).
Even without the law forcing us to control rats I believe we should. I am pretty clear they come under the heading of "invasive non-native" - they colonized the world with man (another invasive non-native ! ).
Mike.